Testosterone Therapy in Women: Revisiting the Evidence
Women’s Health Initiative (WHI), a 2002 study
Women are cautioned against hormone therapy. This study links hormone replacement to breast-cancer risk. However, later analyses reveal the WHI used synthetic progestins, not bioidentical progesterone or testosterone. And the results were misinterpreted and misrepresented. The resulting fear deprived millions of women of therapies that support vitality, sexual health, and overall wellbeing.
Testosterone: A Vital Female Hormone
Women naturally produce more testosterone than estrogen across their lifespan. It influences:
Energy, cognition, mood, and sexual function
Bone and muscle health
Body composition and sleep quality
Deficiency - common by the late 30s or 40s—contributes to fatigue, irritability, weight gain, insomnia, and loss of libido. Yet, few women are tested for or offered testosterone therapy. At physiologic doses, testosterone therapy has proven to be a powerful longevity intervention.
Clinical Evidence
Glaser et al., 2013 (Maturitas): A 9-year study of 2,300 women on testosterone pellets reported a 35 % lower breast-cancer incidence than controls.
Glaser et al., 2019 (BMC Cancer): Extended analysis confirmed reduced breast cancer rates with continued testosterone therapy.
Glaser et al., 2024 (Gavin Publishers): The 15-year Dayton Study (1,200 women) found an incidence of 189 cases/100,000 women-years vs 355 in the general population— nearly a 50 % reduction.
Taranto et al., 2024 (Breast Cancer Research): In breast cancer survivors, topical testosterone improved sexual function without increasing recurrence. These findings suggest that restoring physiologic testosterone may protect against cancer rather than promote it.
Which part of your health is holding everything else back?
Assess your physical, mental/emotional, social, and spiritual health — and get clear on what to focus on first.
